Tularemia: The Silent Killer Known as ‘Rabbit Fever’ That Threatens Human Lives

Tularemia, commonly known as “rabbit fever,” is a contagious disease that primarily affects animals but can also pose a serious risk to humans. This zoonotic infection is often transmitted through bites from ticks and deer flies, making it a concern for those spending time in outdoor or wooded areas.

Tularemia virus

Tularemia, also known as “rabbit fever” or “deer fly fever,” is a rare yet highly infectious disease caused by the bacterium Francisella tularensis. While it primarily affects animals like rabbits, hares, and rodents, humans can also contract the disease through specific exposure routes.

Affected Populations
Tularemia is uncommon in the United States, with only 2,462 cases reported between 2011 and 2022, according to the Centers for Disease Control and Prevention (CDC). Cases have been documented in every U.S. state except Hawaii, with rural areas in Arkansas, Missouri, Oklahoma, and Kansas being hotspots. The disease occurs most frequently from May to September, with children, particularly boys, being more susceptible due to outdoor activities.

Causes and Transmission
The bacterium Francisella tularensis is responsible for tularemia. This microorganism is found throughout the Northern Hemisphere, with occasional appearances in tropical and southern regions. There are four subspecies of F. tularensis, each varying in severity and geographical presence. Type A, the most virulent strain, is specific to North America.

Tularemia is primarily transmitted through:

  • Insect bites: Ticks and deer flies often carry the bacteria.
  • Contaminated water: Drinking infected water can spread the disease.
  • Animal contact: Handling or being bitten by infected animals.

A striking feature of tularemia is its extreme infectivity; as few as 10 to 25 bacterial cells can trigger an infection. However, it cannot spread directly from person to person. Individuals involved in hunting, hiking, camping, or wildlife management are at greater risk.

Symptoms
The symptoms of tularemia depend on how the bacteria enter the body. Common signs include a high fever, sometimes reaching 104°F (40°C).

  • Through the skin: An ulcer may develop at the infection site, along with swollen lymph nodes in the armpit or groin.
  • Through ingestion: Contaminated food or water may cause a sore throat, mouth ulcers, and tonsillitis.

Awareness and prompt medical attention are crucial in managing tularemia effectively.

Tularemia virus

Humans can develop tularemia in numerous ways, including being bitten by ticks that carry the bacteria that cause the disease. (Image credit: CDC Public Health Image Library)

Severe Symptoms
In the most serious cases, tularemia can significantly affect the lungs, particularly when people inhale dust or aerosols containing Francisella tularensis. This mode of transmission can lead to respiratory symptoms such as chest pain, persistent coughing, and difficulty breathing. Additionally, if an untreated F. tularensis infection spreads from other parts of the body to the lungs, these respiratory symptoms may also develop, potentially complicating the patient’s condition.

Treatment Options
Tularemia is treatable, and early medical intervention is key. Broad-spectrum antibiotics, which are effective against a wide range of bacteria, are the primary treatment option. When administered promptly, antibiotics can significantly reduce the disease’s fatality rate from 5–15% to approximately 2%. Despite the availability of effective treatments, there is currently no approved vaccine for tularemia in the United States, which underscores the importance of prevention and early diagnosis.

Preventive Measures
The Centers for Disease Control and Prevention (CDC) recommends several precautions to minimize the risk of tularemia:

  • Use insect repellents: Apply repellents when spending time outdoors to protect against tick and deer fly bites.
  • Wear gloves: Always use gloves when handling sick or dead animals to avoid direct contact with the bacteria.

Adhering to these preventive measures can help reduce exposure to F. tularensis and lower the likelihood of contracting tularemia.

Disclaimer
This article is intended for informational purposes only and does not serve as a substitute for professional medical advice. For specific health concerns, please consult a qualified healthcare provider.